July
2009
Genetic Therapies May Make Promising Treatment for Mesothelioma Compared to Chemotherapy
Oncologists and other cancer doctors decide what type of treatment to pursue with their patient. The options are endless. There are no standard treatment regimen for peritoneal mesothelioma cancer victims. This is because of the relative rareness of the disease, the high mortality rate and low treatment success rate, and the few scientific studies to provide meaningful statistics.
While prospects for patients with mesothelioma have been bleak, doctors have been making progress. Treatments for cancer are traditionally surgery (taking out the tumor and surrounding tissue), radiation (killing the cancerous cells with radiation), and chemotherapy (poisoning the cancerous cells.) There are problems with all three. Patients with mesothelioma have not responded well to traditional radiation therapy. Researchers are looking for ways of aiming radiation directly at the tumor in hopes that this will result in less damage to healthy tissue.
Surgery removes the mesothelial tissue around the tumor. It is a grueling surgery with unknown benefits to patients. Common chemotherapy drugs that work on other types of cancer usually do not work on mesothelioma, and different combinations of chemotherapy drugs have been tried without a lot of success. As with radiation, research is going toward controlling the physical location of the treatment with emphasis on the pleural cavity.
The death rate for mesothelioma is so high that many of even the most sophisticated techniques in cancer treatment are tried out on patients. These include biologic therapy such as the agent interleukin 2 and anti-angiogenesis drugs such as thalidomide. A new drug that has shown results in improving survival is pemetrexed (brand name Alimta).
Before acting, oncologists review the stage of mesothelioma, position of the tumor, and age and health status of the patient. Two exotic ways of attacking mesothelioma are gene therapy and photodynamic therapy. Mesothelioma patients sometimes become involved in clinical trials in this area, and see benefits.
